Microarray Data Integration and Top-down Modeling of Gene Regulation
نویسنده
چکیده
Microarray technologies allow monitoring of gene activity (or expression) of thousands of genes in parallel at the same time. Although very powerful, their complexity makes the observed data very difficult to integrate across experiments. In the first part of this paper I will introduce the microarray technology and several of our bioinformatics approaches for integrating multiple gene expression data sets using combinatorial and visualization methods. In the second part of the paper I will present some thoughts towards formalizing biological models of gene regulation towards a language of transcription.
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